Lessons from Animal Diabetes 8 24-26 July 2001 YASUNORI KANAZAWA, CHAIRPERSON LAD 8 SHIGEHIRO KATAYAMA, CHAIRPERSON JAADR 15 　　The 8th International Workshop on Lessons from Animal Diabetes was held July 24-26, 2001 at Nichidai Kaikan in Tokyo, the same venue where the 3rd Workshop took place in 1990. This issue of Experimental Diabetes Research is dedicated to providing coverage of the highlights of the lectures and communications presented at the workshop. 　　The 8th LAD was organized jointly with the 15th annual meeting of Japan Association of Animal Diabetes Research (JAADR). JAADR is a research group initiated by Professor Yoshio Goto who established the famous GK rat model. There were over 200 participants about one half of them from Japan. Thus, the participants of 8th LAD had an opportunity to interact with many Japanese investigators. There was a novel session on "Animal Models of Diabetes Established in Japan," which gave a special Japanese tone to the meeting. Twelve animal mod-els were presented, many already widely known and oth-ers new that would get into international use soon. 　　Among the important features was the 2nd Renold Memorial Lecture presented by Professor Eleazar Shafrir, entitled "Molecular Background of Nutritionally Induced Insulin Resistance and Leading to Type 2 Diabetes - from Animal Models to Humans" (reprinted in this issue). We also had two plenary lectures by Doctor Palle Serup from Gentofte, Denmark on "Pancreatic stem cells and islet cell differentiation" and by Professor Takashi Kadowaki from the University of Tokyo on "Molecular Pathogenesis of Type 2 diabetes in knockout mice models." LAD 8 com-prised 4 symposia and 3 workshops in which we discussed the genetics and pathogenic mechanisms relevant to human type 1 and type 2 diabetes. We had 95 presentations, including short communications and posters not only related to pathogenesis of diabetes but also results of detailed mapping of genes, pathogenesis of complications and new therapeutic approaches. Abstracts of these com-munications appear in this volume. Listening and dis-cussing these presentations, we felt that studies with ani-mal models are opening new fields of diabetes research and significantly contribute to the understanding of pathogenesis of human diabetes and to the development of new therapeutic modalities. We thank all the partici-pants for their contribution, especially those who came from outside Japan. We were able to make discussions as hot as the weather we had in Tokyo in July during the meeting.

ABSTRACTS

from

The 8th International Workshop on Lessons from Animal Diabetes

joint-by with

The 15th Japan Association of Animal Diabetes Research

CHAIRMAN Y. Kanazawa CO-CHAIRMAN S. Katayama ･ E. Shafrir ･ A.A.F. Sima SECRETARY GENERAL K. Komeda

July 24-26, 2001 Nichidai-kaikan, Tokyo, Japan

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SYMPOSIUM 1 Diabetic Complications Lessons from Animal Models Chairpersons: A. Sima, S. Kawazu CONCURRENT SESSION 1 Transgenic and Knockout Animals Chairpersons: H. Ishida, J. Satoh SYMPOSIUM 2 Obesity and Diabetes Chairpersons: B. Hansen, S. Inoue CONCURRENT SESSION 2 Type II Pathogenesis and New Directions Chairpersons: E. Ziv, Y. Ikeda PLENARY LECTURE 1 Pancreatic Stem Cells and Islet Cell Differentiation Palle Serup, Gentofte, Denmark Chairperson: K. Nanjo POSTER SESSION 1 Complications Chairperson: I. Takei POSTER SESSION 2 Metabolism & Abnormality Chairperson: K. Ono SYMPOSIUM 3 Diabetes Animal Models Established in Japan Chairpersons: A.A. Like, S. Katayama WORKSHOP 1 GK Rat Chairpersons: Y. Goto, P. �stenson WORKSHOP 2 NOD Mice Chairpersons: T. Hanafusa, L. Harrison

WORKSHOP 3 Nutritional Modifications of Animal Models Chairperson: E. Shafrir CONCURRENT SESSION 3 New Topics Chairpersons: K. Yokono, K. Tobe CONCURRENT SESSION 4 Type I Pathogenesis and New Directions Chairpersons: T. Awata, E. Kawasaki CONCURRENT SESSION 5 Gene Analysis Chairpersons: Y. Terauchi, N. Iwasaki CONCURRENT SESSION 6 Complications Chairpersons: J. Nakamura, Y. Iwamoto PANEL SESSION Diabetes Animal Models Established in Japan Coordinators: A.A. Like, K. Nakama, M. Noda POSTER SESSION 3 Type II Pathogenesis and New Directions Chairperson: I. Kimura POSTER SESSION 4 Treatments Chairperson: J. Miyagawa PLENARY LECTURE 2 Molecular Pathogenesis of Type II Diabetes in Knockout Mice Models Takashi Kadowaki, Tokyo Japan Chairperson: Ed Leiter SYMPOSIUM 4 Therapies Lessons from Animal Models Chairpersons: M. Yorek, N. Hotta

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