Date: July 24 (Tue.), 25（Wed.) and 26 (Thu.), 2001
Venue: Nichidai-kaikan
(4-8-24, Kudan-minami, Chiyoda-ku, Tokyo l02-0074, Japan)
Phone＋81-3-3262-2271
Registration: (Desk open: Jul.24 & 25 8:30-17:00 Jul.26 8:30-11:00)
On-site registration desk: All participants should pick up the necessary materials, including name cards upon your arrival at the registration desk. Also, persons who failed to make pre-registration are able to register there.
Registration fees: Active participants (JPY25,000), Students & Young doctors (JPY20,000), Accompanying persons (JPY10,000)
Welcome Reception: (All Registered participants and accompanying persons are invited.)
Date: 18:20～20:00, July 24, 2001
Place: Room A-2 (Auditorium) on 2nd floor
Official Travel Agent:
Kinki Nippon Tourist Co., Ltd. (KNT) has been appointed as official travel agent for this workshop. Inquiries concerning the travel arrangements should be addressed below.
LAD Desk, Event and Conventions, Tokyo, Kinki Nippon Tourist Co., Ltd.
TEL: +81-3-3263-5581 FAX: +81-3-3263-5961 e-mail: LAD@knt-tokyo.gr.jp
Secretariat:
Animal Research Center, Tokyo Medical University, Shinjuku6-1-1,Shinjuku-ku, Tokyo, Japan
Tel: +81-3-3351-6141 Fax:+81-3-3350-8659 E-mail: lad8-iw@tokyo-med.ac.jp
URL: http://jaadr.umin.ac.jp/
Scientific Information
Instruction for Oral Presentation (Concurrent Session)
For oral presentations, one 35mm slide projector or one overhead projector will be available. Video projector and 16mm MOVIE PROJECTORS CANNOT BE USED. All figures and tables are to be prepared in English. Speakers should not exceed their allotted time. (Presentation: 8 minutes and Discussion: 4 minutes)
Instruction for Poster Presentations:
Poster sessions will be held on July 24 and 25. Authors, displaying a poster are requested to be present at your poster during the discussion time. Authors should not exceed their allotted time (5 minutes) at the discussion time.
The dimensions of display space are 90cm wide x 160cm high. The upper 20cm of each panels is for displaying the serial number to identify each presentations (This number will be provided by the secretariat). Authors are requested to prepare a title card for this purpose including the name(s), affiliation(s), and address(es) of the author(s). The size of title card will be 70cm wide x 20cm high.
SCIENTIFIC PROGRAM
July 24 Tuesday, 2001
Room: A-1
9:30-11:10
Symposium 1 “Diabetic Complications Lessons from Animal Models”
Chairpersons: A. Sima, S. Kawazu
SY1-1 C-PEPTIDE DEFICIENCY -A PATHOGENETIC FACTOR IN TYPE 1 DIABETIC COMPLICATIONS
Anders A. F. Sima, Detroit, USA
SY1-2 DIABETIC NEUROPATHY: LESSONS FROM ANIMAL MODELS
Martin Stevens, Ann Arbor, USA
SY1-3 PREVENTION OF NEPHROPATHY: LESSONS FROM ANIMAL MODELS
Masakazu Haneda, Otsu, Japan
SY1-4 A NEW RAT MODEL OF DIABETIC RETINOPATHY
Akihiro Kakehashi, Omiya, Japan
SY1-5 ALTERATION OF VASOACTIVE FACTORS IN CHRONIC DIABETIC COMPLICATION
Subrata Chakrabarti, London, Ontario, Canada
July 24 Tuesday, 2001
Room: A-1
11:10-12:30
Concurrent Session 1″Transgenic and Knockout Animals”
Chairpersons: H. Ishida, J. Satoh
CS1-1 OVEREXPRESSION OF DOMINANT NEGATIVE HNF-1α IN β-CELLS AFFECTS THE MORPHOGENESIS OF ISLETS AND THE PROLIFERATION OFβ-CELLS
Takao Nammo, Suita, Japan
CS1-2 THE ROLE OF SIALIDASE GENE ON INSULIN RESISTANCE; SIALIDASE TRANSGENIC MICE AND HUMAN SIALIDASE GENE POLYMORPHISMS
Yoshinori Hinokio, Sendai, Japan
CS1-3 INCREASED EXPRESSION OF THE STEROL REGULATORY ELEMENTBINDING PROTEIN (SREBP) -1 GENE IN INSULIN RECEPTOR SUBSTRATE -2-/- MOUSE LIVER
Ryo Suzuki, Tokyo, Japan
CS1-4 IRS-2 DEFICIENT MICE SHOWED A MARKED EXACERBATION OF DIABETES UNDER A HIGH-FAT DIET
Kazuyuki Tobe, Tokyo, Japan
CS1-5 IMPACT OF GENETIC BACKGROUND AND ABLATION OF IRS-3 ON IRS-2 KNOCKOUT MICE
Yasuo Terauchi, Tokyo, Japan
CS1-6 INCREASED INSULIN SENSITIVITY DESPITE LIPODYSTROPHY IN HETEROZYGOUS CBP DEFICIENT MICE
Toshimasa Yamauchi, Tokyo, Japan
July 24 Tuesday, 2001
Room: A-1
14:15-15:45
Symposium 2 “Obesity and Diabetes”Chairpersons: B. Hansen, S. Inoue
SY2-1MECHANISMS OF THE PREVENTION OF DIABETES BY MITIGATION OF OBESITY
Barbara C. Hansen, Baltimore, USA
SY2-2 PHYSIOLOGY OF FATLESS MICE
Marc L. Reitman, Bethesda, USA
SY2-3 TRANSGENIC SKINNY MICE OVEREXPRESSING LEPTIN
Yoshihiro Ogawa, Kyoto, Japan
SY2-4 CHARACTERISTICS AND LIMITATIONS OF THE WISTAR FATTY RAT STRAIN AS AN OBESE-DIABETIC MODEL
Hitoshi Ikeda, Osaka, Japan
July 24 Tuesday, 2001
Room: A-1
15:45-17:25
Concurrent Session 2 “Type II Pathogenesis and New Directions”
Chairpersons: E. Ziv, Y. Ikeda
CS2-1 TREATMENT OF NIDDM IN THE GK RAT MODEL BY EXPANSION OF THE β-CELL MASS DURING THE PREDIABETIC PERIOD WITH GLUCAGON-LIKE PEPTIDE-1 OR EXENDIN-4
Bernard Portha, Paris, France
CS2-2 ANTIHYPERGLYCEMIC ACTION OF OREXIN-A AND -B IN FASTING STREPTOZOTOCIN-DIABETIC MICE
Ikuko Kimura, Toyama, Japan
CS2-3 THE EFFECT OF LEPTIN ON APPETITE AND BODY TEMPERATURE IN SPONTANEOUS DIABETIC NAGOYA-SHIBATA-YASUDA(NSY) MOUSE
Koji Nojima, Suita, Japan
CS2-4 PREVENTION AND REVERSAL OF NUTRITIONALLY INDUCED DIABETES IN PSAMMOMYS OBESUS
Ehud Ziv, Jerusalem, Israel
CS2-5 HIGH FAT FEEDING IN THE GOTINGEN MINIPIG IMPAIRS FASTING GLUCOSE AND MARGINALLY DECREASES INSULIN SENSITIVITY
Marianne O. Larsen, Bagsvaerd, Denmark
CS2-6 CHARACTERISATION OF SELECTIVELY BRED DIET INDUCED OBESE RATS AS A MODEL OF IMPAIRED GLUCOSE TOLERANCE AND INSULIN RESISTANCE
Th
ra B. B
dvarsdtir, Bagsvaerd, Denmark
CS2-7 CALPAIN 3 GENE EXPRESSION IN SKELETAL MUSCLE IS ASSOCIATED WITH BODY FAT CONTENT AND MEASURES OF INSULIN RESISTANCE
Ken R. Walder, Victoria, Australia
CS2-8 EFFECT OF IL-1 SECRETED AFTER MODERATE EXERCISE ON BLOOD GLUCOSE LEVEL IN TYPE 2 DIABETES MICE AND NON DIABETIC MICE
Akira Tamagawa, Sendai, Japan
July 24 Tuesday, 2001
Room: A-1
17:25-18:15
Plenary Lecture 1 Chairperson: K. Nanjo
PL-1 PANCREATIC STEM CELLS AND ISLET CELL DIFFERENTIATION
Palle Serup, Gentofte, Denmark
July 24 Tuesday, 2001
Room: A-2
18:20-20:00
Welcome Reception
July 24 Tuesday, 2001
Room: A-2
09:30-18:00
Poster Session(Poster displayed)
13:20-13:45Poster Discussion
Session 1 “Complications” Chairperson: I. Takei
P1-1 MECHANISM OF SODIUM LOAD-INDUCED HYPERTENSION IN WISTAR FATTY RATS: DEFECTIVE DOPAMINERGIC SYSTEM TO INHIBIT Na-K-ATPase ACTIVITY IN RENAL EPITHELIAL CELLS
Takeo Satoh, Kawasaki, Japan
P1-2 INSULIN RECEPTOR ISOFORM EXPRESSION IN SCIATIC NERVE AND DORSAL ROOT GANGLIA IN TYPE I BB/W-, BB/W C-PEPTIDE TREATED AND TYPE II BB/Z-DIABETIC RATS
Anders A. F. Sima, Detroit, USA
P1-3 MOLECULAR PATHOLOGY OF THE NODE OF RANVIER IN TYPE I DIABETIC NEUROPATHY : A ROLE FOR INSULIN AND C-PEPTIDE DEFICIENCIES?
Anders A. F. Sima, Detroit, USA
P1-4 REDUCED PROTEIN KINASE C ACTIVITY IN THE PERIPHERAL NERVE OF DIABETIC MICE OVEREXPRESSING HUMAN ALDOSE REDUCTASE
Shin-Ichiro Yamagishi, Hirosaki, Japan
P1-5 PROLIFERATIVE RETINAL CHANGES IN DIABETIC RATS (WBN/Kob)
Tetsuro Matsuura, Hirakata, Japan
13:45-14:10Poster Discussion
Session 2 “Metabolism & Abnormality” Chairperson: K. Ono
P2-1 INTERRELATION BETWEEN TRP METABOLISM, MET METABOLISM AND ZN2+ IN DIABETIC RATS
Yukio Shibata, Kyoto, Japan
P2-2 HISTOCHEMICAL AND MORPHOMETRICAL ANALYSIS OF SKELETAL MUSCLE IN SPONTANEOUS DIABETIC WBN/KOB RAT
Kiyokazu Ozaki, Hirakata, Japan
P2-3 STIROL FOAM BALLS PLACED IN THE STOMACH PREVENT THE OBESITY AND IMPROVE THE CARBOHYDRATE METABOLISM IN OLETF RATS
Eiji Ohmura, Kawagoe, Japan
P2-4 COMPARISON OF GLUCOKINASE ACTIVITIES IN THE PERIPHERAL LEUKOCYTES BETWEEN DOGS AND CATS
Akio Tanaka, Tokyo, Japan
P2-5 ACTIVITIES OF ENZYMES IN THE MALATE-ASPARTATE SHUTTLE IN THE PERIPHERAL LEUKOCYTES IN DIABETIC DOGS AND CATS
Tsukimi Washizu, Tokyo, Japan
July 25 Wednesday, 2001
Room: A-1
09:00-09:30
General Assembly of 15th JAADR
July 25 Wednesday, 2001
Room: A-1
09:30-10:20
Albert E. Renold Memorial LectureChairperson: Y. Kanazawa
ARLINSULIN RESISTANCE AND BETA CELL LESION INDUCED BY OVERNUTRITION
Eleazar Shafrir, Jerusalem, Israel
July 25 Wednesday, 2001
Room: A-1
10:30-12:00
Symposium 3 “Diabetes Animal Models Established in Japan”
Chairpersons: A. A. Like, S. Katayama
SY3-1 Overview
PRESENT STATUS OF GENETIC ANALYSES OF CAUSATIVE GENES ON THE DIABETIC STRAINS OF MOUSE AND RAT ESTABLISHED IN JAPAN
Kajuro Komeda, Tokyo, Japan
SY3-2 SUSCEPTIBILITY TO DIABETES IS WIDELY DISTRIBUTED IN NORMAL CLASS IIU HAPLOTYPE RATS
K. E. Ellerman, Arthur A. Like, Worcester, USA
SY3-3 RODENT MODELS IN DIABETES RESEARCH: VALUE ENHANCED THROUGH SHARING
Edward H. Leiter, Bar Harbor, USA
SY3-4 A SIGNIFICANCE OF ADIPOSE TISSUE WITH IN OLETF RATS
Tsukasa Hirashima, Tokushima, Japan
July 25 Wednesday, 2001
Room: A-1
14:20-15:40
Workshop 1 “GK Rat”Chairpersons: Y. Goto, P. �stenson
WS1-1 MECHANISMS BEHIND IMPAIRED INSULIN RELEASE IN THE SPONTANEOUSLY DIABETIC GOTO-KAKIZAKI(GK) RAT
Claes-Gran�stenson, Stockholm, Sweden
WS1-2 PATHOPHYSIOLOGY OF GK RATS
Yutaka Seino, Kyoto, Japan
WS1-3GK RATS
Ken-ichi Suzuki, Sendai, Japan
July 25 Wednesday, 2001
Room: A-1
15:40-17:00
Workshop 2 “NOD Mice”
Chairpersons: T. Hanafusa, L. Harrison
WS2-1 PROINSULIN: KEY TO DIABETES PATHOGENESIS AND PREVENTION IN NOD MICE
Leonard C. Harrison, Parkville, Australia
WS2-2 CAUSE, PREVENTION AND CURE OF AUTOIMMUNE DIABETES IN NOD MICE
Ji-Won Yoon, Calgary, Canada
WS2-3 MOLECULAR GENETICS OF TYPE1 DIABETES IN NOD MICE
Hiroshi Ikegami, Suita, Japan
July 25 Wednesday, 2001
Room: A-1
17:00-18:00
Workshop 3 ” Nutritional Modifications of Animal Models”
Chairperson: E. Shafrir
WS3-1 BEACON: A NOVEL GENE INVOLVED IN THE REGULATION OF ENERGY BALANCE
Greg R. Collier, Waurn Ponds, Australia
ZWS3-2 FATTY ACIDS AND MUSCLE INSULIN RESISTANCE: NEW INSIGHTS FROM ANIMAL MODELS
Edward W. Kraegen, Sydney, Australia
WS3-3 NUTRITIONAL MODIFICATION OF INSULIN RESISTANCE IN OLETF RATS
Yutaka Mori, Kawachi-gun, Japan
July 25 Wednesday, 2001
Room: B
11:10-12:00
Concurrent Session 3″New Topics”Chairpersons: K. Yokono, K. Tobe,
CS3-1 β-CELL NEOGENESIS FROM DUCT CELLS IN PARTIAL DUCT-LIGATED MICE
M Li, Suita, Japan
CS3-2 NORMALIZATION OF HYPERGLYCEMIA AFTER ADENOVIRUS-MEDIATED GENE TRANSFER OF IRS-2 INTO IRS-2 DEFICIENT MICE
Masashi Aoyama, Tokyo, Japan
CS3-3 DYSFUNCTION OF GIP/INSULAR AXIS AS PATHOGENESIS OF DIABETES
Katsushi Tsukiyama, Kyoto, Japan
CS3-4 AICAR-TREATMENT IMPROVES GLUCOSE HOMEOSTASIS IN INSULIN RESISTANT DIABETIC (ob/ob) MICE
Juleen R. Zierath, Stockholm, Sweden
CS3-5 GLUCOSE ABSORPTION FROM SMALL INTESTINE IN GK RATS: STUDY WITH THE ISOLATED PERFUSED INTESTINE
Keiichiro Tanigawa, Suzuka, Japan
July 25 Wednesday, 2001
Room: B
14:20-15:20
Concurrent Session 4 “Type I Pathogenesis and New Directions”
Chairpersons: T. Awata, E. Kawasaki
CS4-1 IGF-1 AS TARGET ANTIGEN IN TYPE 1 DIABETES
Keiichi Kodama, Tokyo, Japan
CS4-2 CONTRIBUTION OF Fas/FasL INTERACTION IN THE INITIAL PHASE OF NOD AUTOIMMUNE DIABETES
Maki Nakayama, Kobe, Japan
CS4-3 BLOCKADE OF CD30/CD30L INTERACTION LEADING TO SUPPRESSION OF NOD DIABETES
Sagarika Chakrabarty, Kobe, Japan
CS4-4 HEMATOPOIETIC CELL TRANSPLANTATION FOR AUTOIMMUNE DISEASES: STUDIES IN NOD MICE
Georg F. Beilhack, Stanford, USA
CS4-5 PREVENTION OF DIABETES DEVELOPMENT BY 5α-DIHYDRO-TESTOSTERONE IN FEMALE NOD MICE
Shinichiro Takei , Iruma-gun, Japan
July 25 Wednesday, 2001
Room: B
15:20-16:10
Concurrent Session 5″Gene Analysis”Chairpersons: Y. Terauchi, N. Iwasaki
CS5-1 GENOME ANALYSIS OF THE RAT AUTOIMMUNE TYPE 1 DIABETES LOCUS IDDM/KDP1
Norihide Yokoi, Chiba, Japan
CS5-2 AGE-DEPENDENT EFFECT OF A QTL IN SPONTANEOUS DIABETES MODEL, NAGOYA-SHIBATA-YASUDA(NSY)MOUSE
Michiko I. Babaya, Suita, Japan
CS5-3 GENETIC DISSECTION OF TYPE 2 DIABETES USING CONSOMIC STRAINS CARRYING DIABETOGENIC CHROMOSOMES 11 AND 14 FROM SPONTANEOUSLY DIABETIC NSY MICE
Naru Babaya, Suita, Japan
CS5-4 LINKAGE ANALYSIS OF RESPONSIBLE LOCI FOR GLUCOSE INTOLERANCE IN NON-OBESE SPONTANEOUSLY DIABETIC TORII(SDT)RAT
T. Masuyama, Tokyo, Japan
July 25 Wednesday, 2001
Room: B
16:10-17:10
Concurrent Session 6″Complications” Chairpersons: J. Nakamura, Y. Iwamoto
CS6-1 INHIBITION OF RETINAL FIBRONECTIN OVEREXPRESSION PREVENTS CAPILLARY BASEMENT MEMBRANE THICKENING IN GALACTOSEFED RATS, AN ANIMAL MODEL OF DIABETIC RETINOPATHY
Sayon Roy , Boston, USA
CS6-2 EVIDENCE FOR THE EXISTENCE FOR OXIDATIVE STRESS IN GLOMERULI FROM DIABETIC RATS
Daisuke Koya, Otsu, Japan
CS6-3 ALTERED SENSORY THRESHOLDS
IN DIABETIC RATS Yutaka Kishi, Wakayama, Japan CS6-4THE EFFECT OF C-PEPTIDE ON CELL PROLIFERATION OF HUMAN NEUROBLASTOMA CELL WITH AND WITHOUT INSULIN OR IGF-1 Anders A. F. Sima, Detroit, USA
CS6-5 DOSE DEPENDENT PREVENTION OF EARLY NEUROPATHY IN THE BB/WOR-RAT WITH HUMAN C-PEPTIDE
Anders A. F. Sima, Detroit, USA
July 25 Wednesday, 2001
Room: A-2
12:00-13:10
Panel Session Discussion “Diabetes Animal Models Established in Japan”
Coordinators: A. A. Like, K. Nakama, M. Noda
PD-1 HISTORY OF DERIVATION AND CHARACTERISTICS OF KK STRAIN
Shigehisa Taketomi, Osaka, Japan
PD-2 GK RATS
Ken-ichi Suzuki, Sendai, Japan
PD-3 THE NOD MOUSE, AN ANIMAL MODEL OF TYPE 1 DIABETES: ESTABLISHMENT, CHARACTERISTICS, AND PATHOGENESIS
Susumu Makino, Shiga, Japan
PD-4 THE NSY MOUSE: AN ANIMAL MODEL OF TYPE 2 DIABETES WITH POLYGENIC INHERITANCE
Hiroshi Ikegami, Suita, Japan
PD-5 CHARACTERISTICS OF THE SPONTANEOUS OCCURRING DIABETES (WBN/KOB) RAT
Kazumasa Nakama, Tokyo, Japan
PD-6 THE TSOD MOUSE : A NEW ANIMAL MODEL OF SPONTANEOUS NIDDM WITH OBESITY
Wataru Suzuki, Inashiki-gun, Japan
PD-7 THE OLETF RAT -AS A MODEL FOR HUMAN TYPE II DIABETES- Tsukasa Hirashima, Tokushima, Japan
PD-8 CHARACTERIZATION OF A NEW SPONTANEOUSLY DIABETIC NON-OBESE TORII RAT STRAIN
Masami Shinohara ,Tokyo, Japan
PD-9 THE KDP RAT :AN ANIMAL MODEL OF HUMAN TYPE 1 DIABETES Kajuro Komeda, Tokyo, Japan
PD-10 ALS AND ALR MICE ARE USEFUL DIABETIC MODELS TO REVEAL CORRELATIONS BETWEEN OBESITY AND DIABETES
Tasuku Yamashita, Okayama, Japan
PD-11 CHARACTRIZATION OF AKITA MOUSE
Akio Koizumi, Kyoto, Japan
PD-12 ESTABLISHMENT AND CHARACTERISTICS OF THE WISTAR FATTY RAT
Hiroyuki Odaka, Osaka, Japan
July 25 Wednesday, 2001
Room: A-2
09:30-18:00
Poster Session (Poster displayed)
13:10-13:40 Poster Discussion
Session 3 “Type II Pathogenesis and New Directions”
Chairperson: I. Kimura
P3-1 EFFECT OF DIABETES ON PREDNISOLONE DISPOSITION IN THE RATS
Ryo Murata, Sendai, Japan
P3-2 CHRACTERISTICS OF WBN/Kob-Leprfa, A NEW DIABETIC CONGENIC RAT STRAIN WITH OBESITY
Toshio Akimoto, Tokyo, Japan
P3-3 MORPHOLOGICAL OBSERVATIONS ON THE PANCREATIC ISLETS OF SPONTANEOUS DIABETIC KKAy MICE
Yasuaki Ichikawa, Tokyo, Japan
P3-4 QUANTITATIVE TRAIT LOCUS ANALYSIS FOR CHRONIC PANCREATITIS IN (BNXWBN)F2 PROGENY
Atsushi Tsuji, Hamamatsu, Japan
P3-5 SMALL FIBER NEUROPATHY IN IMPAIRED GLUCOSE TOLERANT (IGT) GK-RATS
Anders A. F. Sima, Detroit, USA
P3-6 HYPERGLYCEMIA INDUCED INTRACELLULAR PROTEIN GLYCATION AND ACTIVATION OF ERK1/2 IN ISCHEMIC AND REPERFUSED RAT HEART
Guang Xu, Tokyo, Japan
13:40-14:05
Poster Discussion
Session 4 “Treatments”
Chairperson: J. Miyagawa
P4-1 EFFECT OF ZINC ACETATE ON GOLD THIOGLUCOSE PRODUCED OBESITY
Reiko Natsuki, Hirakata, Japan
P4-2 ACCUMULATION OF BODY FAT AND INTRA-MUSCULAR FAT IN PIOGLITAZONE-TREATED OLETF RATS AND ITS RELATION TO THE TNF-α mRNA EXPRESSION
Yutaka Mori, Kawachi-gun, Japan
P4-3 THE IMPROVEMENT OF INSULIN SECRETION AFTER SUGAR LOAD WITH NATEGLINIDE IN OLETF RATS- DIFFERENCE IN RESPONSE WITH AGING-
Yutaka Mori, Kawachi-gun, Japan
P4-4 EFFECT OF GLIMEPIRIDE ON THE TNF-α mRNA EXPRESSION IN WHITE ADIPOSE TISSUE AND ITS RELATION TO THE CHANGE IN CELLULARITY-COMPARISON WITH GLIBENCLAMIDE-
Yutaka Mori, Kawachi-gun, Japan
P4-5 ETHYL ACETATE EXTRACT FROM LICORICE ROOT DISPLAYS ANTI-DIABETIC AND ANTI-OBESITY EFFICT ON KK-AY MICE
Kazuma Takahashi, Sendai, Japan
July 26 Thursday, 2001
Room: A-1
09:00-09:50
Plenary Lecture 2Chairperson: Ed. Leiter
PL-2 MOLECULAR PATHOGENESIS OF TYPE 2 DIABETES IN KNOCKOUT MICE MODELS
Takashi Kadowaki, Tokyo, Japan
July 26 Thursday, 2001
Room: A-1
10:00-11:45
Symposium 4 “Therapies Lessons from Animal Models”
Chairpersons: M. Yorek, N. Hotta
SY4-1 ARE RODENT MODELS PREDICTIVE OF DIABETIC NEUROPATHY IN MAN: CASE STUDY FOR ALDOSE REDUCTASE INHIBITORS Thomas C. Hohman, Peapack, USA
SY4-2 ANTIOXIDANT TREATMENT OF STREPTOZOTOCIN-INDUCED DIABETIC RATS: EFFECT ON ENDONEURIAL BLOOD FLOW (EBF), MOTOR NERVE CONDUCTION VELOCITY (MNCV), AND ENDOTHELIAL-DEPENDENT VASCULAR RELAXATION OF EPINEURIAL ARTERIOLES OF THE SCIATIC NERVE
Mark A. Yorek, Iowa, USA
SY4-3 POLYOL-AGE INTERPLAY IN DIABETIC COMPLICATIONS; CLUE FROM ANIMAL MODELS
Soroku Yagihashi, Hirosaki, Japan
SY4-4 AUTOANTIBODY AGAINST Nε– (CARBOXYMETHYL) LYSINE AS A POTENTIAL MAKER FOR DIABETIC NEPHROPATHY AND CHRONIC RENAL FAILURE
Seikoh Horiuchi, Kumamoto, Japan
SY4-5 EMERGING THERAPIES FOR INSULIN RESISTANCE: LESSONS FROM ANIMAL MODELS
Julie S. Moyers, Indianapolis, USA